GABAとベンゾジアゼピン系薬
![](https://igakunote.com/wp-content/uploads/2022/03/D740337D-31C8-4464-81D8-CA5644D78F2C-1.jpg)
GABA(γ-アミノ酪酸)
GABAはGABAA受容体に結合することで細胞内にClイオンを流入させて神経細胞膜電位を過分極にすることで、活動電位発生を抑制して神経抑制効果を発揮するという抑制性神経伝達物質である。興奮性神経伝達物質であるグルタミン酸からグルタミン酸脱炭酸酵素の働きによって作られる。
GABAA受容体
GABAA受容体にはGABA結合部位のみではなく、ベンゾジアゼピン系薬やバルビツール酸系薬やアルコール・揮発性麻酔薬など多くの薬剤との結合部位が存在する。これらの薬剤はGABAA受容体の作用を増強させることで効果を発揮する。
ベンゾジアゼピン系薬
ベンゾジアゼピン系薬には抗不安作用・催眠作用(傾眠作用)・抗けいれん作用・筋弛緩作用などの臨床的薬理作用がある。これらの作用に伴って、海馬の活動性を抑制してしまうことで服用後の記憶が障害される前向健忘やふらついて転倒するといった有害事象が起こる。
また、アルコール離脱症状に対しては敢えてベンゾジアゼピン系薬を用いることで身体を偽飲酒状態にして騙す。これはベンゾジアゼピン系薬とアルコールのGABA受容体に結合する部位が一緒だということを利用している。
一般的なせん妄は抗精神病薬で治療するのに対してアルコール離脱せん妄はベンゾジアゼピン系薬で治療する。アルコール離脱せん妄に対する予防投与としてベンゾジアゼピン系薬が用いられることが医師国家試験ではしばしば出題される。
ベンゾジアゼピン離脱症候群
ベンゾジアゼピンには依存性と耐性があることが分かっている。使用するにつれて薬剤の用量がどんどん増えていくのにも関わらずどんどん効かなくなっていき、飲むのを止めるとベンゾジアゼピン離脱症候群が起こるので止めることができないという状況に陥ることがある。
深刻な睡眠障害・不安の増加・けいれん発作・自立神経過活動(発汗・動悸)といった症状が出る。
参考文献
GABAA受容体応答の制御機構:https://www.jstage.jst.go.jp/article/hirosakiigaku/66/2-4/66_105/_pdf/-char/ja
GABA-A受容体作動薬における薬物依存:https://www.kyorin-pharm.co.jp/prodinfo/useful/doctorsalon/upload_docs/161160-1-23.pdf
コメント
Very nice post and straight to the point. I am not sure if this is
in fact the best place to ask but do you
people have any thoughts on where to get some professional writers?
Thanks in advance 🙂 Escape rooms hub
You have observed very interesting details! ps nice site.?
Right here is the right web site for everyone who wants to understand this topic. You understand a whole lot its almost hard to argue with you (not that I actually would want to…HaHa). You definitely put a fresh spin on a subject that has been written about for a long time. Wonderful stuff, just great.
Everything is very open with a precise explanation of the challenges. It was definitely informative. Your website is useful. Thank you for sharing.
Pretty! This was a really wonderful post. Thanks for supplying this info.
Hello there! This post couldn’t be written much better! Looking through this post reminds me of my previous roommate! He continually kept talking about this. I will forward this post to him. Fairly certain he’s going to have a great read. Thank you for sharing!
I must thank you for the efforts you’ve put in penning this blog. I really hope to view the same high-grade content from you in the future as well. In fact, your creative writing abilities has encouraged me to get my very own site now 😉
Hi there! This post couldn’t be written much better! Looking through this article reminds me of my previous roommate! He always kept talking about this. I most certainly will forward this article to him. Pretty sure he’s going to have a great read. Thank you for sharing!
You ought to be a part of a contest for one of the best websites on the internet. I will recommend this web site!
I like looking through a post that will make men and women think. Also, many thanks for allowing me to comment.
Hi there! I could have sworn I’ve visited this web site before but after looking at many of the articles I realized it’s new to me. Nonetheless, I’m certainly pleased I stumbled upon it and I’ll be book-marking it and checking back frequently.
An outstanding share! I’ve just forwarded this onto a coworker who had been doing a little research on this. And he actually ordered me dinner because I discovered it for him… lol. So let me reword this…. Thank YOU for the meal!! But yeah, thanx for spending some time to talk about this topic here on your internet site.
Way cool! Some very valid points! I appreciate you penning this post and also the rest of the website is very good.
It’s difficult to find educated people about this subject, but you sound like you know what you’re talking about! Thanks
Hi, I do believe this is an excellent web site. I stumbledupon it 😉 I am going to come back once again since I book marked it. Money and freedom is the best way to change, may you be rich and continue to guide other people.
This is the perfect web site for everyone who really wants to find out about this topic. You realize a whole lot its almost tough to argue with you (not that I really will need to…HaHa). You definitely put a fresh spin on a subject that has been written about for a long time. Wonderful stuff, just great.
Aw, this was a really good post. Taking a few minutes and actual effort to produce a great article… but what can I say… I procrastinate a whole lot and never seem to get nearly anything done.
I could not resist commenting. Very well written.
Hi there! This blog post could not be written any better! Looking through this article reminds me of my previous roommate! He continually kept preaching about this. I will forward this article to him. Fairly certain he’ll have a great read. Thank you for sharing!
Nice post. I learn something new and challenging on websites I stumbleupon every day. It will always be helpful to read content from other authors and use a little something from their sites.
Excellent post! We will be linking to this great article on our site. Keep up the good writing.
Hi, I do think this is an excellent blog. I stumbledupon it 😉 I will return yet again since I saved as a favorite it. Money and freedom is the best way to change, may you be rich and continue to guide other people.
Hello! I just wish to offer you a huge thumbs up for your great information you have got here on this post. I’ll be returning to your website for more soon.
I blog often and I truly appreciate your content. This article has really peaked my interest. I’m going to bookmark your blog and keep checking for new details about once a week. I subscribed to your RSS feed as well.
An outstanding share! I’ve just forwarded this onto a colleague who had been conducting a little homework on this. And he actually ordered me breakfast due to the fact that I stumbled upon it for him… lol. So let me reword this…. Thanks for the meal!! But yeah, thanks for spending the time to discuss this issue here on your web page.
A fascinating discussion is worth comment. I do believe that you ought to write more on this subject matter, it may not be a taboo subject but typically folks don’t talk about these subjects. To the next! Best wishes.
Good site you have here.. It’s difficult to find quality writing like yours nowadays. I honestly appreciate people like you! Take care!!
Great information. Lucky me I discovered your blog by chance (stumbleupon). I’ve bookmarked it for later.
I’m very pleased to discover this site. I want to to thank you for ones time just for this fantastic read!! I definitely savored every bit of it and I have you saved to fav to see new stuff in your web site.
I used to be able to find good info from your articles.
Everyone loves it when folks come together and share thoughts. Great site, stick with it!
This website truly has all of the info I wanted about this subject and didn’t know who to ask.
After I initially commented I seem to have clicked on the -Notify me when new comments are added- checkbox and from now on every time a comment is added I get 4 emails with the exact same comment. Perhaps there is a means you are able to remove me from that service? Thanks.
That is a good tip particularly to those new to the blogosphere. Simple but very accurate information… Thank you for sharing this one. A must read post.
Pretty! This was an extremely wonderful post. Thanks for providing these details.
There is definately a great deal to learn about this subject. I really like all the points you made.
May I simply say what a comfort to uncover somebody that really knows what they’re discussing on the internet. You actually realize how to bring a problem to light and make it important. A lot more people have to check this out and understand this side of your story. I can’t believe you are not more popular given that you definitely have the gift.
Pretty! This was an extremely wonderful post. Thank you for supplying this info.
May I simply just say what a comfort to uncover somebody that truly knows what they’re discussing on the web. You certainly know how to bring an issue to light and make it important. More and more people really need to check this out and understand this side of your story. I was surprised you aren’t more popular since you surely have the gift.
I blog often and I truly appreciate your information. Your article has truly peaked my interest. I’m going to book mark your site and keep checking for new details about once a week. I subscribed to your RSS feed as well.
It’s hard to come by experienced people in this particular subject, but you sound like you know what you’re talking about! Thanks
Next time I read a blog, Hopefully it doesn’t fail me as much as this one. After all, Yes, it was my choice to read through, however I really believed you would have something useful to talk about. All I hear is a bunch of whining about something that you could fix if you weren’t too busy seeking attention.
This blog was… how do you say it? Relevant!! Finally I’ve found something that helped me. Kudos.
Great info. Lucky me I discovered your blog by accident (stumbleupon). I have book-marked it for later.
I blog frequently and I really thank you for your content. This great article has truly peaked my interest. I am going to bookmark your blog and keep checking for new information about once a week. I subscribed to your RSS feed too.
I love reading a post that will make men and women think. Also, many thanks for allowing for me to comment.
There is certainly a lot to find out about this subject. I really like all of the points you’ve made.
After exploring a number of the blog articles on your web page, I seriously like your way of blogging. I saved it to my bookmark website list and will be checking back in the near future. Please check out my web site as well and tell me your opinion.
I couldn’t refrain from commenting. Exceptionally well written!
This website was… how do you say it? Relevant!! Finally I have found something which helped me. Kudos!
Hi there! This post couldn’t be written much better! Reading through this post reminds me of my previous roommate! He constantly kept talking about this. I’ll forward this article to him. Fairly certain he will have a good read. Thanks for sharing!
I’m very pleased to find this site. I need to to thank you for ones time due to this fantastic read!! I definitely loved every part of it and i also have you book marked to see new information in your blog.
I truly love your site.. Pleasant colors & theme. Did you create this website yourself? Please reply back as I’m attempting to create my own personal website and would like to find out where you got this from or what the theme is called. Cheers.
You are so interesting! I don’t believe I’ve read through something like that before. So good to find somebody with some original thoughts on this subject matter. Really.. thanks for starting this up. This web site is something that’s needed on the internet, someone with a bit of originality.
This excellent website certainly has all the info I needed about this subject and didn’t know who to ask.
After looking at a few of the blog articles on your web page, I really like your way of blogging. I book marked it to my bookmark site list and will be checking back in the near future. Please visit my website too and let me know what you think.
You’ve made some really good points there. I checked on the net for more information about the issue and found most individuals will go along with your views on this site.
Hi, I believe your blog may be having web browser compatibility issues. When I take a look at your site in Safari, it looks fine however, when opening in Internet Explorer, it’s got some overlapping issues. I just wanted to give you a quick heads up! Besides that, wonderful site!
There’s certainly a great deal to find out about this issue. I like all the points you’ve made.
You should be a part of a contest for one of the most useful blogs on the net. I most certainly will recommend this web site!
I’m impressed, I have to admit. Rarely do I encounter a blog that’s both equally educative and entertaining, and let me tell you, you’ve hit the nail on the head. The issue is something that not enough people are speaking intelligently about. Now i’m very happy that I came across this during my search for something concerning this.
Everything is very open with a precise clarification of the challenges. It was truly informative. Your website is very useful. Thank you for sharing!
I’m amazed, I have to admit. Seldom do I encounter a blog that’s equally educative and engaging, and let me tell you, you’ve hit the nail on the head. The issue is something that not enough folks are speaking intelligently about. I am very happy that I stumbled across this during my hunt for something concerning this.
This is the right website for everyone who really wants to find out about this topic. You realize a whole lot its almost tough to argue with you (not that I actually will need to…HaHa). You certainly put a brand new spin on a subject that has been discussed for many years. Excellent stuff, just excellent.
Right here is the right webpage for anybody who really wants to understand this topic. You know so much its almost tough to argue with you (not that I actually will need to…HaHa). You certainly put a fresh spin on a topic that has been written about for years. Great stuff, just wonderful.
This blog was… how do you say it? Relevant!! Finally I’ve found something that helped me. Kudos!
When I initially left a comment I appear to have clicked on the -Notify me when new comments are added- checkbox and from now on every time a comment is added I recieve 4 emails with the same comment. There has to be a means you can remove me from that service? Thanks.
Great article. I will be going through a few of these issues as well..
After checking out a few of the blog articles on your blog, I honestly like your technique of blogging. I book marked it to my bookmark webpage list and will be checking back soon. Please check out my website as well and tell me your opinion.
Greetings! Very helpful advice within this post! It is the little changes that will make the most significant changes. Many thanks for sharing!
Pretty! This was an extremely wonderful article. Many thanks for providing this information.
Hey there! I just want to offer you a huge thumbs up for the great information you have got here on this post. I will be coming back to your website for more soon.
I’m amazed, I have to admit. Rarely do I come across a blog that’s equally educative and amusing, and without a doubt, you have hit the nail on the head. The problem is an issue that too few people are speaking intelligently about. Now i’m very happy I found this during my hunt for something concerning this.